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Chung-Yi Chen Selected Research

isoobtusilactone A

4/2012Isoobtusilactone A sensitizes human hepatoma Hep G2 cells to TRAIL-induced apoptosis via ROS and CHOP-mediated up-regulation of DR5.
6/2008Anticancer activity of isoobtusilactone A from Cinnamomum kotoense: involvement of apoptosis, cell-cycle dysregulation, mitochondria regulation, and reactive oxygen species.
8/2007Isoobtusilactone A induces cell cycle arrest and apoptosis through reactive oxygen species/apoptosis signal-regulating kinase 1 signaling pathway in human breast cancer cells.
7/2007Isoobtusilactone A-induced apoptosis in human hepatoma Hep G2 cells is mediated via increased NADPH oxidase-derived reactive oxygen species (ROS) production and the mitochondria-associated apoptotic mechanisms.

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Chung-Yi Chen Research Topics

Disease

20Neoplasms (Cancer)
11/2021 - 02/2006
10Melanoma (Melanoma, Malignant)
03/2022 - 08/2011
8Breast Neoplasms (Breast Cancer)
03/2022 - 08/2007
5Mouth Neoplasms (Oral Cancer)
10/2021 - 08/2010
4Inflammation (Inflammations)
03/2022 - 12/2014
4Neoplasm Metastasis (Metastasis)
08/2021 - 01/2012
4Colorectal Neoplasms (Colorectal Cancer)
01/2017 - 03/2009
4Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2013 - 11/2007
4Hepatocellular Carcinoma (Hepatoma)
04/2012 - 02/2006
3Corneal Neovascularization
04/2018 - 11/2009
3Lung Neoplasms (Lung Cancer)
01/2013 - 03/2011
2Neuroinflammatory Diseases
03/2022 - 06/2020
2Urinary Bladder Neoplasms (Bladder Cancer)
11/2021 - 12/2011
2Prostatic Neoplasms (Prostate Cancer)
11/2019 - 09/2017
2Wounds and Injuries (Trauma)
02/2013 - 01/2012
2Skin Neoplasms (Skin Cancer)
01/2013 - 08/2011
2Retinoblastoma (Glioblastoma, Retinal)
10/2012 - 02/2006
2Carcinoma (Carcinomatosis)
09/2011 - 03/2011
1Lymphatic Metastasis
08/2021
1Squamous Cell Carcinoma of Head and Neck
10/2018
1Sepsis (Septicemia)
12/2017
1Aberrant Crypt Foci
01/2017
1Carcinogenesis
01/2017
1Cicatrix (Scar)
01/2015
1Melanosis (Freckles)
01/2015
1Acne Vulgaris
01/2015

Drug/Important Bio-Agent (IBA)

9Reactive Oxygen Species (Oxygen Radicals)IBA
04/2021 - 07/2007
6AntioxidantsIBA
03/2022 - 06/2010
4LipopolysaccharidesIBA
03/2022 - 12/2017
4Antineoplastic Agents (Antineoplastics)IBA
01/2020 - 01/2012
4kotomolide AIBA
01/2020 - 11/2007
4CaspasesIBA
11/2016 - 02/2007
4isoobtusilactone AIBA
04/2012 - 07/2007
3Pharmaceutical PreparationsIBA
10/2018 - 12/2010
3anonaineIBA
04/2014 - 08/2008
36-dehydrogingerdioneIBA
02/2013 - 05/2010
3Proteins (Proteins, Gene)FDA Link
10/2012 - 02/2007
3isooctyl acrylateIBA
04/2012 - 08/2007
2Adenosine Triphosphate (ATP)IBA
03/2022 - 11/2016
2PhytochemicalsIBA
09/2018 - 09/2017
2sinularinIBA
07/2018 - 04/2018
2hexahydrocurcuminIBA
04/2018 - 11/2011
2Monophenol Monooxygenase (Tyrosinase)IBA
01/2018 - 03/2011
2Dinoprostone (PGE2)FDA Link
12/2017 - 12/2014
2Nitric Oxide (Nitrogen Monoxide)FDA Link
12/2017 - 12/2014
2benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketoneIBA
11/2016 - 01/2013
2Annexin A5IBA
11/2016 - 01/2013
27-hydroxydehydronuciferineIBA
12/2015 - 11/2014
2Bevacizumab (Avastin)FDA Link
04/2013 - 10/2012
2pigment epithelium-derived factorIBA
04/2013 - 11/2009
2subamolide AIBA
01/2013 - 09/2011
2liriodenineIBA
04/2012 - 09/2011
2ThapsigarginIBA
02/2012 - 08/2010
2shogaolIBA
08/2010 - 02/2007
2gingerolIBA
03/2009 - 01/2008
1gingerenone AIBA
03/2022
1p38 Mitogen-Activated Protein KinasesIBA
03/2022
16-methoxyflavoneIBA
03/2022
1CurcuminIBA
03/2022
1FlavonoidsIBA
03/2022
1Cysteine (L-Cysteine)FDA Link
11/2021
1rhopaloic acid AIBA
11/2021
1Superoxides (Superoxide)IBA
10/2021
1Caspase 3 (Caspase-3)IBA
10/2021
1AcidsIBA
10/2021
1Acetylcysteine (Siran)FDA LinkGeneric
10/2021
1Biological ProductsIBA
08/2021
1AMP-Activated Protein KinasesIBA
04/2021
1diacetyldichlorofluoresceinIBA
04/2021
1Anti-Inflammatory Agents (Anti-Inflammatories)IBA
06/2020
1hispidulinIBA
06/2020
1secokotomolide AIBA
01/2020
1Docosahexaenoic AcidsIBA
11/2019
1Interleukin-8 (Interleukin 8)IBA
11/2019
1Interleukin-6 (Interleukin 6)IBA
11/2019
1Fish OilsIBA
11/2019
1syringinIBA
08/2019
1cembraneIBA
10/2018
1sandensolideIBA
10/2018
1Toll-Like Receptor 4IBA
09/2018
1SaltsIBA
04/2018
11-methyl-4-(9-dioleyl)methylpyridiniumIBA
04/2018
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
04/2018
1Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA
04/2018
1PheophytinsIBA
12/2017
1CytokinesIBA
12/2017
1Adenosine Monophosphate (AMP)IBA
11/2017
1obtusilactone AIBA
11/2017
1Docetaxel (Taxotere)FDA Link
09/2017
1AzoxymethaneIBA
01/2017
1DNA (Deoxyribonucleic Acid)IBA
11/2016
1tenuifolide BIBA
11/2016
1Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
11/2016
1Propidium (Propidium Iodide)IBA
11/2016
1Melanins (Melanin)IBA
01/2015

Therapy/Procedure

4Drug Therapy (Chemotherapy)
03/2022 - 06/2008
4Chemoprevention
09/2018 - 07/2007
3Therapeutics
08/2021 - 03/2015
2Radiotherapy
03/2015 - 02/2007
1Heterologous Transplantation (Xenotransplantation)
11/2021